AUTHOR=Wang Yue , Jiang Guannan , Zhang Jie , Wang Jingfeng , You Wanchun , Zhu Juehua 

TITLE=Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1120779

DOI=10.3389/fendo.2023.1120779

ISSN=1664-2392

ABSTRACT=Background and objectives: Intravenous recombinant tissue plasminogen activator (rtPA) thrombolysis is an effective treatment for actue ischemic stroke. Hyperglycemia is a major risk factor for the occurrence, development, and prognosis of ischemic stroke. This meta-analysis purposefully estimates the association between hyperglycemia and poor prognosis in acute ischemic stroke patients receiving intravenous rtPA thrombolytic therapy.
Materials and methods: According to the predefined inclusion criteria, we searched PubMed, Web of Science, and Cochrane Library databases. The association of high blood glucose(>140mg/dl) with symptomatic intracranial hemorrhage (SICH), poor clinical outcome and mortality at 90 days post rtPA thrombolysis was studied using both a common effects model and a random effects model. Odds ratios (a ORs) were plotted on forest plots.
Results: Of a total cohort of 2565 patients who received intravenous thrombolytic therapy, 721 had higher blood glucose. High glucose level significantly increased the odds of SICH (OR 1.80; 95% confidence interval(95%CI): 1.30- 2.50) and poor clinical outcome at 90 days (OR 1.82; 95%CI: 1.52-2.19), and all-cause mortality at 90 days (OR 2.51; 95%CI:1.65-3.82).
Conclusions: In our meta-analysis, high blood glucose was significantly associated with SICH, poor clinical outcome and mortality at 90 days.