AUTHOR=Wang Hengyi , Zhu Jianshu , Xia Yuanliang , Li Yuehong , Fu Changfeng 

TITLE=Application of platelet-rich plasma in spinal surgery

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1138255

DOI=10.3389/fendo.2023.1138255

ISSN=1664-2392

ABSTRACT=With the technological advancement and social progress of the world today, spine-related diseases have become a major global public health concern. This will undoubtedly bring a huge economic burden to the family and society. Spinal diseases and complications can lead to loss of motor, sensory, and autonomic functions. Therefore, it is necessary to identify effective treatment strategies. Currently, the treatment of spine-related diseases includes conservative, surgical, and minimally invasive interventional therapies. However, these different treatment methods have important drawbacks. Examples include drug tolerance and dependence, adjacent spondylosis, secondary surgery, infection, nerve injury, dural rupture, nonunion, and pseudoarthrosis. Further, it is even more difficult to promote the regeneration of the interstitial disc and restore its biomechanical properties. Therefore, in response to the above problems, clinicians urgently need to identify methods that can limit disease progression or cure diseases at the etiological level. Platelet-rich plasma (PRP), a platelet-rich form of plasma extracted from venous blood, is a blood-derived product. Alpha granules contain a large number of cytokines, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor, platelet factor 4 (PF-4), insulin-like growth factor-1 ( growth factors such as IGF-1), and transforming growth factor-β (TGF-β). These growth factors allow stem cell proliferation and angiogenesis, promote bone regeneration, improve the local microenvironment, and enhance the tissue regeneration capacity and functional recovery. This review describes the application of PRP in the treatment of spine-related diseases and discusses the clinical application of PRP in spinal surgery.