AUTHOR=Zeng Qiaoli , Tan Bing , Han Fengqiong , Huang Xiujuan , Huang Jinzhi , Wei Yue , Guo Runmin 

TITLE=Association of solute carrier family 30 A8 zinc transporter gene variations with gestational diabetes mellitus risk in a Chinese population

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1159714

DOI=10.3389/fendo.2023.1159714

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>The <italic>solute carrier family 30 A8 zinc transporter</italic> (<italic>SLC30A8</italic>) plays a crucial role in insulin secretion. This study aimed to investigate the impact of <italic>SLC30A8</italic> gene polymorphisms on gestational diabetes mellitus (GDM).</p></sec><sec><title>Methods</title><p>The research objective was to select 500 patients with GDM and 502 control subjects. Rs13266634 and rs2466293 were genotyped using the SNPscan™ genotyping assay. Statistical tests, such as the chi-square test, t-test, logistic regression, ANOVA, and meta-analysis, were conducted to determine the differences in genotypes, alleles, and their associations with GDM risk.</p></sec><sec><title>Results</title><p>Statistically significant differences were observed in age, pregestational BMI, SBP, DBP, and parity between individuals with GDM and healthy subjects (<italic>P</italic> &lt; 0.05). After adjusting for these factors, rs2466293 remained significantly associated with an increased risk of GDM in overall subjects (GG+AG vs. AA: OR = 1.310; 95% CI: 1.005-1.707; <italic>P</italic> = 0.046, GG vs. AA: OR = 1.523; 95% CI: 1.010-2.298; <italic>P</italic> = 0.045 and G vs. A: OR = 1.249; 95% CI: 1.029-1.516; <italic>P</italic> = 0.024). Rs13266634 was still found to be significantly associated with a decreased risk of GDM in individuals aged ≥ 30 years (TT vs. CT+CC: OR = 0.615; 95% CI: 0.392-0.966; <italic>P</italic> = 0.035, TT vs. CC: OR = 0.503; 95% CI: 0.294-0.861; <italic>P</italic> = 0.012 and T vs. C: OR =0.723; 95% CI: 0.557-0.937; <italic>P</italic> = 0.014). Additionally, the haplotype CG was found to be associated with a higher risk of GDM (<italic>P</italic> &lt; 0.05). Furthermore, pregnant women with the CC or CT genotype of rs13266634 exhibited significantly higher mean blood glucose levels than those with the TT genotype (<italic>P</italic> &lt; 0.05). Our findings were further validated by the results of a meta-analysis.</p></sec><sec><title>Conclusion</title><p>The <italic>SLC30A8</italic> rs2466293 polymorphism was found to be associated with an increased risk of GDM, while rs13266634 was associated with a decreased risk of GDM in individuals aged ≥ 30 years. These findings provide a theoretical basis for GDM testing.</p></sec>