AUTHOR=Cho So Hyun , Kim Seohyun , Lee You-Bin , Jin Sang-Man , Hur Kyu Yeon , Kim Gyuri , Kim Jae Hyeon 

TITLE=Impact of continuous glucose monitoring on glycemic control and its derived metrics in type 1 diabetes: a longitudinal study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1165471

DOI=10.3389/fendo.2023.1165471

ISSN=1664-2392

ABSTRACT=<sec><title>Aim</title><p>We explored the effectiveness of continuous glucose monitoring for 1 year on glycated A1c reduction in adults with type 1 diabetes mellitus.</p></sec><sec><title>Methods</title><p>We included type 1 diabetes mellitus adults who were either new continuous glucose monitoring users (<italic>N</italic> = 155) or non-users who were under standard care (<italic>N</italic> = 384). Glycated A1c was measured at baseline and 3, 6, 9, and 12 months. Individuals with (<italic>N</italic> = 155) or without continuous glucose monitoring use (<italic>N</italic> = 310) were matched 1:2 by propensity score. We used the linear mixed models to identify the quantitative reduction in repeated measures of glycated A1c.</p></sec><sec><title>Results</title><p>The change in glycated A1c from baseline to 12 months was −0.5% ± 1.0% for the continuous glucose monitoring user group (<italic>N</italic> = 155, <italic>P</italic> &lt; 0.001) and −0.01% ± 1.0% for the non-user group (<italic>N</italic> = 310, <italic>P</italic> = 0.816), with a significant difference between the two groups (<italic>P</italic> = 0.003). Changes in glycated A1c were significant at 3, 6, 9, and 12 months compared with those at baseline in patients using continuous glucose monitoring (<italic>P</italic> &lt; 0.001), and the changes differed significantly between the groups (<italic>P</italic> &lt; 0.001). A linear mixed model showed an adjusted treatment group difference in mean reduction in glycated A1c of −0.11% (95% confidence interval, −0.16 to −0.06) each three months. In the continuous glucose monitoring user group, those who achieved more than 70% of time in range significantly increased from 3 months (37.4%) to 12 months (48.2%) (<italic>P</italic> &lt; 0.001).</p></sec><sec><title>Conclusion</title><p>In this longitudinal study of type 1 diabetes mellitus adults, the use of continuous glucose monitoring for 1 year showed a significant reduction in glycated A1c in real-world practice.</p></sec>