AUTHOR=Wang Siqi , Wu Zhixin , Chen Yang , Luo Kuanhong , Cui Zhenhai , Zhang Jiaoyue , Zheng Juan , Xiao Kangli , Li Huiqing 

TITLE=Comparative efficacy of aromatase inhibitors and gonadotropin-releasing hormone analogue in increasing final height of idiopathic short stature boys: a network meta-analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1167351

DOI=10.3389/fendo.2023.1167351

ISSN=1664-2392

ABSTRACT=Objective To investigate the efficacy of the monotherapy with AIs or GnRHa in improving the height in boys with idiopathic short stature (ISS).
Method  We performed a systematic search in Pubmed, The Cochrane Library, Chinese National Knowledge Infrastructure databases, and Wanfang Database for eligible studies. The network meta-analysis was conducted by the STATA software.
Results We identified a total of 4 studies that included 136 individuals. We used FAH /PAH as the main outcome of final height. The results revealed a statistically higher final height after treatment of AI or GnRHa in idiopathic short stature children(MD= 4.63, 95% CI[3.29,5.96]). In network meta-analysis, the direct and indirect comparison between AI and GnRHa was presented in the forest plot. Compared with control group, both AI and GnRHa were effective in increasing the final height, with the mean effect of 4.91(95%CI:1.10,8.17) and 5.55(95%CI:1.12,9.98) respectively. However, there was no statistical difference between the GnRHa and AI treatment, of which the mean effect was 0.65(95%CI: -4.30,5.60).
Conclusion Both AIs and GnRHa monotherapy were effective in augmenting the final height of boys with idiopathic short stature when compared to placebo groups. However, there was no statistical difference between the GnRHa and AI treatment.