AUTHOR=Zhou Lingling , Qu Huanjia , Zhang Qiuling , Hu Jinhua , Shou Lan 

TITLE=Case report: Fulminant type 1 diabetes following paucisymptomatic SARS-CoV-2 infection during late pregnancy

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1168927

DOI=10.3389/fendo.2023.1168927

ISSN=1664-2392

ABSTRACT=Background 
Dysregulation of glucose metabolism has been linked to SARS-CoV-2 infection. In addition, occurrence of new onset diabetes mellitus, including fulminant type 1 diabetes has been reported after SARS-CoV-2 infection or vaccination.
Methods and results
A young Chinese female in her last trimester of pregnancy presented with an abrupt progression of hyperglycemia and ketoacidosis but a near-normal glycohemoglobin following paucisymptomatic SARS-CoV-2 infection. The low C peptide level, fasting and postprandial, reflected profound insulin deficiency in the setting of negative islet autoantibody testing, consistent with a diagnosis of fulminant type 1 diabetes. Ketoacidosis and hyperglycemia quickly improved following introduction of insulin therapy, but not the β cell function. She received treatment with an insulin pump therapy since being discharged, and the first follow-up revealed a well-controlled glucose profile.
Conclusions
New-onset FT1D after SARS-CoV-2 infection can occur. Our report raises awareness of this rare but serious situation to promote early recognition and management of FT1D during the COVID-19 pandemic.