AUTHOR=Ivić Vedrana , Zjalić Milorad , Blažetić Senka , Fenrich Matija , Labak Irena , Scitovski Rudolf , Szűcs Kálmán Ferenc , Ducza Eszter , Tábi Tamás , Bagamery Fruzsina , Szökő Éva , Vuković Rosemary , Rončević Alen , Mandić Dario , Debeljak Željko , Berecki Monika , Balog Marta , Seres-Bokor Adrienn , Sztojkov-Ivanov Anita , Hajagos-Tóth Judit , Gajović Srećko , Imširović Alen , Bakula Marina , Mahiiovych Solomiia , Gaspar Robert , Vari Sandor G. , Heffer Marija 

TITLE=Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1181064

DOI=10.3389/fendo.2023.1181064

ISSN=1664-2392

ABSTRACT=
The aim of the study was to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Elderly Sprague-Dawley rats, 45 weeks old, were randomized into 4 groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M), or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after introduction of diet and lasted 13 weeks, until the animals were 64 weeks old. Unexpectedly, HFHSD fed animals did not gain weight, but nevertheless underwent significant metabolic change. Both antidiabetic treatments produced sex-specific effects, but neither prevented onset of prediabetes nor diabetes. Liraglutide vested benefits to liver and skeletal muscle tissue in males, but induced signs of insulin resistance in females.