AUTHOR=Yang Ming , Liu Chongbin , Jiang Na , Liu Yan , Luo Shilu , Li Chenrui , Zhao Hao , Han Yachun , Chen Wei , Li Li , Xiao Li , Sun Lin 

TITLE=Endoplasmic reticulum homeostasis: a potential target for diabetic nephropathy

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1182848

DOI=10.3389/fendo.2023.1182848

ISSN=1664-2392

ABSTRACT=The endoplasmic reticulum (ER), as the most vigorous organelle in intracellular metabolism, is involved in physiological processes such as protein and lipid synthesis and calcium ion transport. Recently, abnormal function of ER has also been reported to be involved in the progression of kidney disease especially in diabetic nephropathy (DN). Here, we reviewed the function of ER and summarized the regulation of homeostasis through UPR and ER-phagy. Then, we also reviewed the role of abnormal ER homeostasis in residential renal cells of DN. Finally, part of ER stress activator and inhibitors were also summarized, and discussed the possibility of maintaining ER homeostasis as a potential therapeutic target for DN.