AUTHOR=Wang Wencai , Ma Luyao , Zhao Yongqiang , Liu Menghao , Ye Wei , Li Xianfeng 

TITLE=Research progress on the role of the Wnt signaling pathway in pituitary adenoma

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1216817

DOI=10.3389/fendo.2023.1216817

ISSN=1664-2392

ABSTRACT=Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear.The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Selfrenewal of stem cells, and cell differentiation. It is related to the occurrence of various tumors, including PA. This article reviews the latest developments in Wnt pathway inhibitors and pathway-targeted drugs. It discusses the possibility of combining Wnt pathway inhibitors with immunotherapy to provide a theoretical basis for the combined treatment of PA.