AUTHOR=Zhang Li , Wang Yuan-yuan , Zheng Xiao-ying , lei Li , Tang Wen-hao , Qiao Jie , Li Rong , Liu Ping 

TITLE=Novel predictors for livebirth delivery rate in patients with idiopathic non-obstructive azoospermia based on the clinical prediction model

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1233475

DOI=10.3389/fendo.2023.1233475

ISSN=1664-2392

ABSTRACT=Objective: To build a prediction model for livebirth delivery per intracytoplasmic sperm injection (ICSI) in iNOA patients obtaining sperm by microdissection testicular sperm extraction (mTESE).Methods: A retrospective cohort study of 377 couples with iNOA male partners treated with 519 mTESE-ICSI cycles was conducted from September 2013 to July 2021 at the Reproductive Medical Centre of Peking University Third Hospital. Following exclusions, 377 couples with iNOA male partners treated with 482 mTESE-ICSI were included. The prediction model for livebirth delivery per ICSI cycle was built by multivariable logistic regression and selected by 10-fold cross-validation.Discrimination was evaluated by c-statistic and calibration was evaluated by calibration slope.Results: Livebirth delivery rate per mTESE-ICSI cycle was 39.21% (189/482) in these couples. The model identified that presence of motile sperm during mTESE, bigger testes, higher endometrial thickness on the day of human chorionic gonadotrophin (hCG) administration (ET-hCG) and more high quality embryos are associated with higher livebirth delivery success rates. The results of the model were exported based on 10-fold cross-validation. In addition, the area under the mean ROC curve was 0.71±0.05 after 10-fold cross-validation, indicating that the prediction model had certain prediction precision. Calibration plot with the estimated intercept of -1.653 (95% CI: -13.403 to 10.096) and the slope of 1.043 (95% CI: 0.777 to 1.308) indicating that the model was wellcalibrated.Conclusion: Our prediction model will provide valuable information about the chances of livebirth delivery in couples with iNOA male partners who have a plan for mTESE-ICSI treatment. Therefore, it can improve and personalize counselling for medical treatment of these patients.