AUTHOR=Wang Ying , Liu Tongtong , Cai Yuzi , Liu Weijing , Guo Jing 

TITLE=SIRT6’s function in controlling the metabolism of lipids and glucose in diabetic nephropathy

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1244705

DOI=10.3389/fendo.2023.1244705

ISSN=1664-2392

ABSTRACT=Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) and the main cause of excess 16
mortality in patients with type 2 DM. The pathogenesis and progression of DN are closely associated 17
with disorders of glucose and lipid metabolism. As a member of the sirtuin family, SIRT6 has 18
deacetylation, defatty-acylation, and adenosine diphosphate-ribosylation enzyme activities as well as 19
anti-aging and anticancer activities. SIRT6 plays an important role in glucose and lipid metabolism 20
and signaling, especially in DN. SIRT6 improves glucose and lipid metabolism by controlling 21
glycolysis and gluconeogenesis, affecting insulin secretion and transmission and regulating lipid 22
decomposition, transport, and synthesis. Targeting SIRT6 may provide a new therapeutic strategy for 23
DN by improving glucose and lipid metabolism. This review elaborates on the important role of 24
SIRT6 in glucose and lipid metabolism, discusses the potential of SIRT6 as a therapeutic target to 25
improve glucose and lipid metabolism and alleviate DN occurrence and progression of DN, and 26
describes the prospects for future research.