AUTHOR=Shen Chongrong , Chen Yanru , Wang Qiaoling , Sun Yingkai , Lin Huibin , Ni Mengshan , Chen Yufei , Zhang Ling , Jin Jiabin , Ying Xiayang , Zou Yuyao , Wang Xiaolin , Ye Yaorui , Yuan Miaomiao , Yin Nan , Cao Zhiwen , Zhang Yifei , Gu Weiqiong , Wang Weiqing , Ning Guang , Wang Jiqiu , Zhao Shaoqian , Hong Jie , Liu Ruixin 

TITLE=Fecal short chain fatty acids modify therapeutic effects of sleeve gastrectomy

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1277035

DOI=10.3389/fendo.2023.1277035

ISSN=1664-2392

ABSTRACT=Aims: We aimed to investigate changes of fecal short chain fatty acids (SCFAs) and their association with metabolic benefits after sleeve gastrectomy (SG). Specifically, whether pre-surgery SCFAs modify surgical therapeutic effects was determined.

Methods: 62 participants with measurements of fecal SCFAs and metabolic indices before and 1, 3, 6 months after SG were included. Changes of fecal SCFAs and their association with post-surgery metabolic benefits was calculated. Then, participants were stratified by medians of pre-surgery fecal SCFAs and modification effects of pre-surgery fecal SCFAs on surgical therapeutic effects were investigated, through calculating interaction of group by surgery.

Results: Fecal SCFAs were markedly changed by SG. Changes of propionate and acetate were positively correlated with serum triglycerides and total cholesterol, respectively. Notably, high pre-surgery fecal hexanoate group showed a better effect of SG treatment on lowering body weight (P=0.01), BMI (P=0.041) and serum triglycerides (P=0.031), and low pre-surgery fecal butyrate had a better effect of SG on lowering ALT (P=0.003) and AST (P=0.019).

Conclusions: Fecal SCFAs were changed and correlated with lipid profiles improvement after SG. Pre-surgery fecal hexanoate and butyrate were potential modifiers impacting metabolic benefits of SG.