AUTHOR=Tang Mulin , Meng Xue , Ni Jiajia , Liu Xue , Wang Xinhui , Li Yuchen , Chai Yuwei , Kou Chunjia , Zhang Li , Zhang Haiqing 

TITLE=The interference of anti-TSH autoantibody on clinical TSH detection

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1289923

DOI=10.3389/fendo.2024.1289923

ISSN=1664-2392

ABSTRACT=Objective: It is well known that Macro-TSH may interfere with the detection of TSH. Anti-TSH autoantibody is the essential component of Macro-TSH. However, it is unclear about the epidemiological characteristics and clinical interference of anti TSH autoantibody.
Methods: We used the radioimmunoprecipitation technique to detect anti-TSH autoantibody. Platforms with different detection mechanisms were applied to detect TSH in patients with anti-TSH autoantibody. PEG precipitation was used to determine the immunoassay interference.
Results: The prevalence of anti-TSH autoantibody in patients who have mild SCH and have autoimmune thyroiditis but normal thyroid function is 4.78%. All 10 patients with anti-TSH antibodies have autoimmune diseases, 5 of them have significant-clinical test interference.
Conclusions: The appearing of anti-TSH antibody is not associated with thyroid autoantibodies. The presence of anti-TSH autoantibody can interfere with the detection of TSH and affect clinical diagnosis and treatment.