AUTHOR=Wang Suijian , Wang Kui , Chen Xiaohong , Chen Daiyun , Lin Shaoda 

TITLE=Autoimmune thyroid disease and myasthenia gravis: a study bidirectional Mendelian randomization

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1310083

DOI=10.3389/fendo.2024.1310083

ISSN=1664-2392

ABSTRACT=Previous studies have suggested a potential association between AITD and MG, but the evidence is limited and controversial, and the exact causal relationship remains uncertain.Therefore, we employed a Mendelian randomization (MR) analysis to investigate the causal relationship between AITD and MG. 2 Methods To explore the interplay between AITD and MG, We conducted MR studies utilizing GWAS-based summary statistics in the European ancestry.Several techniques were used to ensure the stability of the causal effect, such as random-effect inverse variance weighted, weighted median, MR-Egger regression, and MR-PRESSO. Heterogeneity was evaluated by calculating Cochran's Q value. Moreover, the presence of horizontal pleiotropy was investigated through MR-Egger regression and MR-PRESSO Results