AUTHOR=Hu Jingwen , Chen Lin , Ruan Jing , Chen Xiaoyan 

TITLE=The role of the annexin A protein family at the maternal–fetal interface

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1314214

DOI=10.3389/fendo.2024.1314214

ISSN=1664-2392

ABSTRACT=Successful pregnancy requires the tolerance of the maternal immune system for the semi-allogeneic embryo, as well as a synchrony between the receptive endometrium and the competent embryo.Annexin family belongs to calcium-regulated phospholipid-binding protein, which functions as membrane skeleton to stabilize lipid bilayer and participate in a wide range of biological processes in humans. There is an abundance of annexin family at the maternal-fetal interface and exert a crucial role in embryo implantation and the subsequent development of the placenta. Altered expression of annexin family and dysfunction of annexin proteins or polymorphisms of ANXA gene are involved in a range of pregnancy complications. In this review, we summarize the current knowledge of the annexin A protein family at the maternal-fetal interface and its association with female reproductive disorders, suggesting the use of ANXA as the potential therapeutic target in the clinical diagnosis and treatment of pregnancy complications.