AUTHOR=Shu Hongmin , Xu Huimin , Pan Zixiang , Liu Yan , Deng Wei , Zhao Ren , Sun Yan , Wang Zhen , Yang Jinxiu , Gao Hui , Yao Kaixuan , Zheng Jie , Yu Yongqiang , Li Xiaohu 

TITLE=Early detection of myocardial involvement by non-contrast T1ρ mapping of cardiac magnetic resonance in type 2 diabetes mellitus

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1335899

DOI=10.3389/fendo.2024.1335899

ISSN=1664-2392

ABSTRACT=Objective: This study aims to determine the effectiveness of T1ρ in detecting myocardial fibrosis in type 2 diabetes mellitus (T2DM) patients by comparing with native T1 and Extracellular volume (ECV) fraction.
Methods: T2DM patients (n=35) and healthy controls (n=30) underwent cardiac magnetic resonance. ECV, T1ρ, native T1, and global longitudinal strain (GLS) values were assessed. Diagnostic performance was analyzed using receiver operating curves.
Results: The global ECV and T1ρ of T2DM group (ECV = 32.1±3.2%, T1ρ = 53.1±2.0 msec) were significantly higher than those of controls (ECV = 26.2±1.6 %, T1ρ = 51.6±3.8 msec) (all P < 0.001), whether there was no significant difference in native T1 between T2DM and controls (P = 0.264). The GLS decreased significantly in T2DM patients compared with controls (-16.5±2.4% vs. -18.3±2.6%, P = 0.015). The T1ρ and native T1 were associated with ECV (Pearson’s r = 0.50 and 0.25, respectively, both P < 0.001), the native T1, T1ρ, and ECV were associated with hemoglobin A1c (Pearson’s r = 0.41, 0.52, and 0.61, respectively, all P < 0.05), the ECV were associated with diabetes duration (Pearson’s r = 0.41, P = 0.016). The AUC of ECV, T1ρ, GLS, and native T1 were 0.869, 0.810, 0.659, and 0.524, respectively.
Conclusion: In T2DM patients, T1ρ may be a new noncontrast cardiac magnetic resonance technique for identifying myocardial diffuse fibrosis, and T1ρ may be more sensitive than native T1 in the detection of myocardial diffuse fibrosis.