AUTHOR=Jiménez Amanda , Vlacho Bogdan , Mata-Cases Manel , Real Jordi , Mauricio Dídac , Franch-Nadal Josep , Ortega Emilio 

TITLE=Sex and age significantly modulate cardiovascular disease presentation in type 2 diabetes: a large population-based cohort study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1344007

DOI=10.3389/fendo.2024.1344007

ISSN=1664-2392

ABSTRACT=Aims: We aimed to describe and compare the incidence of the first cardiovascular event and its major subtypes, coronary heart disease (CHD), cerebrovascular disease, heart failure (HF), or peripheral artery disease (PAD), according to age and sex in a population-based cohort of individuals with type 2 diabetes (T2D) from a Mediterranean region.We used linked primary care electronic medical reports, pharmacy-invoicing data, and hospital admission disease registry records from the SIDIAP database, which contains linked data for 74% of the Catalonian population. We selected individuals with T2D aged 30 to 89 years free of cardiovascular disease (CVD). The primary outcome was the first presentation of CVD.Results: The study cohort included 247,751 individuals (48.6% women, 66.8±11.9 years). During a 6.99-year follow-up, the cumulative incidence of the first cardiovascular event was 23.4%. Men were at higher risk for CVD (hazard ratio [