AUTHOR=Du Siyu , Zhao Jieyi , Chou Xinyue , Peng Jingyu , Cao Qi , Zeng Yimiao , Ao Lu , Wang Xiaoyu 

TITLE=Testosterone does not mediate the correlation between dietary inflammation and serum klotho levels among males: insights from NHANES database

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1370457

DOI=10.3389/fendo.2024.1370457

ISSN=1664-2392

ABSTRACT=Serum Klotho (S-Klotho) is a transmembrane protein holds pivotal roles in antiaging. The Dietary Inflammation Index (DII), a meticulously dietary tool, quantifies the inflammatory potential of an individual's diet. The existing research strongly suggests that a low DII diet plays a significant role in delaying aging and reducing aging-related symptoms in males. Testosterone could potentially act as a mediating intermediary between DII and S-Klotho. However, this aspect remains unexplored. This study aims to investigate the potential causal link of testosterone between DII and S-Klotho in males. We utilized data from National Health and Nutrition Examination Survey (NHANES) which focused on male participants from 2013-2016. Mediation analyses were used to investigate the effects of testosterone (TT), free testosterone (FT), and free androgen index (FAI) on the DII-S-Klotho relationship, using three modes adjusting for covariates. Mediation analysis unveiled a significant inverse correlation between DII and S-Klotho levels