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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Renal Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1390725
This article is part of the Research Topic Advancements in Nutritional Management for Patients with Renal Failure View all articles

Association between Waist Triglyceride Index(WTI), Body Mass Index(BMI), Dietary Inflammatory Index(DII) and Triglyceride-Glucose Index(TyG) with Chronic Kidney Disease: the 1999-2018 cohort study from NHANES

Provisionally accepted
Zhiyu Li Zhiyu Li Zhongping Xu Zhongping Xu Chenhao Xuan Chenhao Xuan Hongyang Xu Hongyang Xu *
  • The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, wuxi, China

The final, formatted version of the article will be published soon.

    Purpose: To compare the dietary inflammatory index (DII), triglyceride glucose index (TyG), waist triglyceride index (WTI), and body mass index (BMI) in predicting the survival of chronic kidney disease (CKD).Methodology: Inclusion of 23,099 participants from the NHANES database who met specific criteria. Baseline was established using quartiles of DII index. The relationship between DII index, WTI index, TyG index, and BMI index with mortality rate in CKD patients was evaluated using Kaplan-Meier curves. Univariate and multivariate COX regression risk models were used to study the relationship between DII index, WTI index, and TyG index with mortality risk in CKD patients.Stratification of eGFR by age and gender was conducted to investigate the association between DII index, WTI index, and TyG index with mortality risk in CKD patients. Restricted cubic spline analysis was used to study the correlation between DII index, WTI index, and TyG index with mortality risk in CKD patients. The incidence of CKD increased with the increase of DII index, WTI index and TyG index.After multivariable adjustment, the fourth quartile of DII index, TyG index and WTI index showed the highest risk for CKD [DII: hazard ratio (HR) 1.36, 95% confidential interval (CI) (1.23-1.51); TyG: HR 1.21; 95% CI (1.07-1.37); WTI: HR 1.29; 95% CI (1.13-1.46)]. There was no difference in the risk of developing CKD between the obese group (BMI ≥24 kg/m2) and the normal weight group (P>0.05).This study has identified a significant association between elevated DII index, WTI index, and TyG index with the risk of CKD. Furthermore, the DII index demonstrated superior prognostic capability in predicting CKD compared to other indicators.

    Keywords: Dietary Inflammatory Index1, Triglyceride Glucose Index2, Waist Triglyceride Index3, Body mass index4, chronic kidney disease5

    Received: 23 Feb 2024; Accepted: 16 Jul 2024.

    Copyright: © 2024 Li, Xu, Xuan and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hongyang Xu, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, wuxi, China

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