Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1404747
This article is part of the Research Topic The Prevention and Treatment of Diabetic Osteoporosis View all articles

Metabolic factors are not the direct mediators of the association between type 2 diabetes and osteoporosis

Provisionally accepted
  • 1 Department of Orthopedics, the First Affiliated Hospital of Jilin University, Changchun, Hebei Province, China
  • 2 Jinan Maternity And Child Care Hospital, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    The causal relationship between type 2 diabetes mellitus (T2DM) and osteoporosis (OS) remains unclear. This study aims to investigate the causal relationship and explore the potential metabolic mechanism and its mediating role.We conducted a comprehensive study, gathering data on 490,089 T2DM patients from the genome-wide Association Study (GWAS) database and selecting OS data from FinnGen and MRC-IEU sources, including 212,778 and 463,010 patients, respectively, for causal analysis.Simultaneously, we explored the potential roles of three obesity traits and 30 metabolic and inflammation-related mediating variables in the causal relationship.There is a strong causal relationship between T2DM and OS. The data from our two different database sources appeared in the same direction, but after correcting for BMI, WC, and WHR, the direction became the same. Results: T2DM may increase the risk of OS (OR > 1.5, P < 0.001). Steiger test results show that there is no reverse causality. No risk factors related to glycolipid metabolism, amino acid metabolism and inflammatory were found to mediate the causal relationship.This study's findings indicate a robust causal relationship between T2DM and OS, influenced by relevant factors such as BMI. Our results shed light on the pathogenesis of OS and underscore the importance for clinicians treat metabolic disorders to prevent osteoporosis.

    Keywords: T2DM, type 2 diabetes mellitus, Osteoporosis, os, Mendelian randomization

    Received: 21 Mar 2024; Accepted: 09 Jul 2024.

    Copyright: © 2024 Yang, Wang, Liu, Liu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dong Zhu, Department of Orthopedics, the First Affiliated Hospital of Jilin University, Changchun, Hebei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.