AUTHOR=Liang Caixia , Lu Hongjian , Wang Xueqin , Su Jianbin , Qi Feng , Shang Yanxing , Li Yu , Zhang Dongmei , Duan Chengwei 

TITLE=Neuron stress-related genes serve as new biomarkers in hypothalamic tissue following high fat diet

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1443880

DOI=10.3389/fendo.2024.1443880

ISSN=1664-2392

ABSTRACT=Objective: Energy homeostasis is modulated by the hypothalamic is essential for obesity progression, however, the gene expression profiling remains to be fully understood.Methods: GEO datasets were downloaded from the GEO website and analysed by the R packages to obtain the DEGs. And, the WGCNA analysis and PPI networks of co-expressed DEGs were designed using STRING to get key genes. In addition, the single-cell sequencing datasets and GTEx database were utilized to receive the neuron-stress genes from the key genes. Further, high-fat diet (HFD)-induced hypothalamic tissue of mice was