AUTHOR=Zhang Daqi , Spisani Jerry , Ceriello Arianna , Frattini Francesco , Brucchi Francesco , Dionigi Gianlorenzo , Wan Lanlan , Angileri Alessio Salvatore , Colombo Carla , Ierardi Anna Maria , Carrafiello Gianpaolo TITLE=Navigating the complexity of current interventional radiological approaches for distant metastases in thyroid cancer JOURNAL=Frontiers in Endocrinology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1445855 DOI=10.3389/fendo.2025.1445855 ISSN=1664-2392 ABSTRACT=The finding of liver metastases in thyroid cancer is relatively uncommon. Treatment is complex and depends on several factors, including location, number and size of lesions, associated symptoms, extrahepatic disease and patient’s condition. In this context, interventional radiological treatments have been successfully used to optimize disease control or for palliative purposes and have generally been well tolerated. However, careful selection of candidates for such procedures in a multidisciplinary context is crucial.