AUTHOR=Yang Kun , Sang Yanmei , Dai Li , Wang Weizhong TITLE=Central precocious puberty associated with duplicated pituitary: a case report and literature review JOURNAL=Frontiers in Endocrinology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1466411 DOI=10.3389/fendo.2025.1466411 ISSN=1664-2392 ABSTRACT=Patients with duplicated pituitary often have severe neurodevelopmental abnormalities and craniofacial deformities. Till now, only eight patients diagnosed with duplicated pituitary showing barely central precocious puberty (CPP) are reported in the published literature. Herein, we report a 6-year-old and 3-month-old girl diagnosed with pituitary duplication presented with CPP. She has enlarged breasts for more than 1 year, accelerated height of linear growth, advanced bone age, increased hormone level, and increased volume of uterus and ovary. A duplicated pituitary gland was shown in the MRI. As the gonadotropin-releasing hormone analogue (GnRHa) stimulation test showed a positive result, the child was treated with GnRHa. After 2 years of follow-up, there was a delay in the progression of sexual development, a reduction in symptoms of precocious puberty, and an increase in predicted adult height.