AUTHOR=Zheng Yinuo , Zhuang Yizhen , Zhou Peng 

TITLE=Evaluation of conditional survival outcomes in patients with redefined anaplastic thyroid carcinoma

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1525869

DOI=10.3389/fendo.2025.1525869

ISSN=1664-2392

ABSTRACT=ObjectiveConditional survival (CS) offers a more precise assessment of prognosis by continuously updating to reflect the current state. This study aimed to analyze the CS outcome of redefined anaplastic thyroid carcinoma (rATC).MethodsA cohort comprising 1424 patients diagnosed with rATC between 2000 and 2018 was extracted from the Surveillance, Epidemiology, and End Results database and subsequently divided into training and validation sets at a ratio of 3:1. We analyzed the CS prognosis of these patients. A Lasso Cox regression model was employed to determine independent risk factors for long-term survival and to develop a predictive nomogram integrating CS analysis, aiming to provide CS estimates and stratify the risk among rATC patients.ResultsThe likelihood of achieving 5-year CS escalated from 8% after diagnosis to 44%, 68%, 82%, and 95% after 1, 2, 3, and 4 years of survival, respectively. As patients endured longer, their probability of further years of survival augmented. The Lasso Cox regression analysis identified age, tumor stage, surgery, radiotherapy and chemotherapy as the most influential prognostic factors associated with outcomes. Ultimately, we successfully established a novel CS-nomogram, aiming to provide dynamic survival updates for these patients. Our predictive model can quantify patients’ risk and stratify it accordingly. Furthermore, after evaluation, the performance of our predictive model was found to be satisfactory.ConclusionUtilizing extensive SEER datasets, we devised and validated a CS-nomogram, enabling the prediction of the conditional probability of survival for rATC patients. This facilitates the incorporation of survivorship duration into prognostic assessments.