AUTHOR=Li Jiyuan , Qiao Jiashen , Li Yihan , Qin Gaofeng , Xu Yingjiang , Lao Kaixue , Wang Yanlin , Fan Yang , Tang Peiyi , Han Lei 

TITLE=Metabolic disorders in polycystic ovary syndrome: from gut microbiota biodiversity to clinical intervention

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1526468

DOI=10.3389/fendo.2025.1526468

ISSN=1664-2392

ABSTRACT=Polycystic ovary syndrome (PCOS) is a prevalent gynecologic endocrine disorder characterized by menstrual irregularities, elevated androgen levels, and ovulatory dysfunction. Its etiology is multifactorial. Emerging evidence indicates that PCOS patients exhibit diminished gut microbiota (GM) diversity and altered microbial ratios, contributing to the metabolic derangements observed in these individuals. This review elucidates the role of GM in the pathogenesis and metabolic disorders of PCOS, encompassing insulin resistance (IR), hormonal imbalances, bile acid metabolic disorders, Interleukin-22-mediated immune dysregulation, and brain-gut axis disturbances. Additionally, it synthesizes current therapeutic strategies targeting the GM, aiming to furnish a theoretical framework for prospective clinical interventions.