AUTHOR=Riobó Adriana , Martínez Acosta Andrea , Martinez-Rocca Lorena , Taboas Esther , López de Uralde Belén , Fernandez Iria , Garrido Nicolás , Muñoz Elkin 

TITLE=Dual triggering for final oocyte maturation. A narrative review

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1556732

DOI=10.3389/fendo.2025.1556732

ISSN=1664-2392

ABSTRACT=The dual triggering combines human chorionic gonadotropin (hCG) with GnRH agonists (aGnRH) to induce the final oocyte maturation in in vitro fertilization (IVF). When both drugs are used sequentially, it is called “double trigger”, but this strategy is rarely used clinically. This review explores the rationale for using dual triggering and compares its reproductive outcome with conventional hCG triggering. Variability in protocols, inclusion criteria, study aims, and weak study designs complicate the evaluation of its clinical benefit. Patients with low response or cycles with high proportion of immature oocytes (>25%) may benefit from dual triggering. In contrast, patients with normal or hyper responsiveness show no significant differences compared to conventional hCG triggering. Further robust studies are needed to clarify the clinical applications of dual triggering. Until then, this strategy should remain part of research protocols rather than routine clinical practice.