AUTHOR=Yue Yong , Li Pengcheng , Sun Zhengyu , Wang Xiaoyi , Li Zongping , Zhang Ye 

TITLE=Unveiling the role of stress hyperglycemia in predicting mortality for critically ill hemorrhagic stroke patients: insights from MIMIC-IV

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1558352

DOI=10.3389/fendo.2025.1558352

ISSN=1664-2392

ABSTRACT=BackgroundHemorrhagic stroke (HS), including intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), is associated with high mortality and morbidity. Stress hyperglycemia ratio (SHR), reflecting acute glycemic responses relative to baseline glucose levels, has been linked to poor outcomes in critical illnesses. However, research on its prognostic significance in HS patients admitted to the intensive care unit (ICU) is limited. This study aims to assess the association between SHR and all-cause mortality (ACM) in critically ill HS patients.MethodsPatients diagnosed with HS were extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database using ICD-9/10 codes. SHR was calculated as [admission glucose (mg/dL)/(28.7 × HbA1c (%) − 46.7)]. Patients were stratified into tertiles. Primary outcomes were ICU, in-hospital, 30-day, 90-day, 180-day, and 1-year mortality. Cox regression and restricted cubic splines (RCS) evaluated the dose-response relationship between SHR and ACM. Kaplan-Meier (K-M) analysis assessed survival across tertiles, with subgroup analysis and interaction tests for effect modification.ResultsThe study included 1,749 patients, with a median age of 68 years (IQR: 57–79), and 53.2% were male. The observed mortality rates were 10.6% in the ICU, 15.2% in-hospital, 19.6% at 30 days, 24.2% at 90 days, 27.8% at 180 days, and 31.7% at 1 year. Multivariate Cox regression analysis indicated that elevated SHR was independently associated with increased ACM at 30 days (adjusted hazard ratio [aHR]: 1.41; 95% confidence interval [CI]: 1.10–1.81; P = 0.006), 90 days (aHR: 1.33; 95% CI: 1.08–1.65; P = 0.008), and 1 year (aHR: 1.27; 95% CI: 1.05–1.54; P = 0.014). RCS analysis demonstrated a linear association between SHR and ACM, with no evidence of non-linearity. Subgroup analysis revealed consistent associations across various patient characteristics.ConclusionSHR is significantly associated with ACM in critically ill patients with HS, supporting its potential role as a prognostic marker for risk stratification and guiding clinical management. Incorporating SHR into routine risk assessment may facilitate early identification of high-risk patients, enabling timely interventions and improved outcomes.