AUTHOR=Zhao Bo , Yu Zongliang , Tang Fengyan , Feng Zhenqin , Wang Junfeng , Wang Zhaoxiang 

TITLE=Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1560577

DOI=10.3389/fendo.2025.1560577

ISSN=1664-2392

ABSTRACT=PurposeThe estimated glucose disposal rate (eGDR) serves as a straightforward and noninvasive indicator of insulin resistance (IR). This study aims to explore the association between eGDR and the risk of abdominal aortic calcification (AAC).MethodsWe utilized data from adult participants (≥40 years old, n=3006) from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) database. AAC was measured by dual-energy X-ray absorptiometry and quantified using the Kauppila score. Severe AAC (SAAC) was defined as an AAC score > 6. Logistic regression, restricted cubic spline (RCS), and subgroup analysis were used to analyze the relationship between eGDR and SAAC risk.ResultsIn fully adjusted models, eGDR was found to be negatively associated with SAAC (OR=0.86, 95%CI:0.79–0.94, P<0.001). Compared to participants in the lowest eGDR quantile, those in the highest quantile exhibited a lower risk of SAAC (OR=0.47, 95%CI:0.25–0.91, P=0.026). The RCS analysis indicates a nonlinear relationship between eGDR and SAAC risk, with a turning point at 7.05 mg/kg/min. Subgroup analysis showed that the association between eGDR and SAAC risk was more significant in women.ConclusionsThe degree of IR assessed by eGDR is associated with SAAC risk. The eGDR shows promise as an epidemiological tool for evaluating the influence of IR on AAC.