AUTHOR=Wang Haiqiang , Shi Fan , Zheng Lihong , Zhou Wenhui , Mi Bowen , Wu Siyu , Feng Xiaoling 

TITLE=Gut microbiota has the potential to improve health of menopausal women by regulating estrogen

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1562332

DOI=10.3389/fendo.2025.1562332

ISSN=1664-2392

ABSTRACT=Menopause is an age-related loss of ovarian function. As a woman enters menopause, the estrogen produced by her ovaries decreases, which will adversely affect women’s health. The symptoms related to menopause are related to the imbalance of gut microbiota. Studies have shown that the diversity of gut microbiota after menopause is lower than that before menopause, and the weakening of microbial decomposition will lead to the decrease of circulating estrogen, gradually resulting in disorders of lipid metabolism, cognitive decline, osteoporosis and other diseases. Gut microbiota play a key role in regulating estrogen levels. By secreting β-glucuronidase, it increases the reabsorption of estrogen in the enterohepatic circulation and mediates phytoestrogen metabolism, regulates estrogen homeostasis in the host and affects disease development and prognosis. Therefore, the gut microbiota is an overall regulator of women’s estrogen status during menopause and an untapped new area for improving women’s postmenopausal health. Changing the gut microbiota through specific prebiotics, probiotics, etc., and then affecting estrogen levels provides exciting opportunities for future therapeutic applications.