AUTHOR=Shomali Mansur , Kumbara Abhimanyu , MacLeod Janice , Iyer Anand TITLE=Personalized cardiometabolic care powered by artificial intelligence JOURNAL=Frontiers in Endocrinology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1593321 DOI=10.3389/fendo.2025.1593321 ISSN=1664-2392 ABSTRACT=Advancements in artificial intelligence (AI) are providing a wealth of opportunities for improving clinical practice and healthcare delivery. It is predicted by AI experts that healthcare will change more in the next decade than it has in the previous century due to the volume and speed of these advancing capabilities. In this paper, we will illustrate the potential value of AI by sharing an example of an AI-powered digital health platform, designed to support people living with chronic cardiometabolic conditions and their care teams. The goal is to transform the care continuum from prevention through diagnosis, treatment, and ongoing management, including efficient acute care interventions when needed. The intent is to shift from reactive to proactive care including preventive-based guidance and interventions. AI-powered health technologies enable true person-centered care (i.e., for N=1), but for entire populations at scale (i.e., N >> 1), shifting the traditional mass generalization paradigm to one of mass customization. We demonstrate how an AI-powered digital health platform: 1) supports early detection and diagnosis of chronic conditions such as diabetes and related cardiometabolic conditions with data and insights; 2) optimizes personalized treatment; 3) tracks progress; 4) provides education; and 5) enables longitudinal behavior change to sustain health. We will present current AI capabilities as well as future considerations for the industry. We will also discuss principles that govern the responsible adoption of AI capabilities in healthcare to complement, not replace, the clinician.