AUTHOR=Wang Yongchao , Cheng Tiantian , Zhang Tie , Guo Rubing , Ma Liang , Zhao Wei 

TITLE=Association of triglyceride glucose index with incident diabetes among individuals with normal fasting triglycerides and fasting plasma glucose values: a general population-based retrospective cohort study

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1598171

DOI=10.3389/fendo.2025.1598171

ISSN=1664-2392

ABSTRACT=IntroductionThe triglyceride glucose (TyG) index has been proposed as a reliable surrogate marker for insulin resistance. Previous studies have demonstrated a significant positive association between the TyG index and diabetes risk. However, whether this association persists among individuals with normal fasting triglyceride (TG) and fasting plasma glucose (FPG) levels remains unclear. This study aims to evaluate the relationship between the TyG index and diabetes in this specific population utilizing a large-scale population-based dataset.MethodsA total of 155,337 subjects (74,622 males and 80,715 females) were included in this retrospective cohort study. The TyG index was calculated using the formula: ln [TG (mg/dL) × GLU (mg/dL)/2]. Cox regression analyses were utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). A generalized additive model (GAM), combined with smooth curve fitting, was employed to investigate potential nonlinear associations. Subgroup analyses were stratified by age, sex, body mass index, and family history of diabetes.ResultsDuring a 3.13-year mean follow-up, 1127 subjects (0.73%) developed diabetes. After adjusting for confounding variables, subjects in the highest quartile of baseline TyG index exhibited an increased risk of diabetes compared to those in the lowest quartile (adjusted HR: 3.80; 95% CI: 2.41-5.99; P for trend < 0.001). Furthermore, a nonlinear threshold association was identified, with an inflection point at a TyG index value of 8.41. For subjects with a TyG index greater than 8.41, the adjusted HR was 15.33 (95% CI: 7.3-32.2, P < 0.001). Subgroup analysis revealed a stronger positive correlation in individuals aged <60 years.DiscussionThis large-scale study demonstrates a robust independent association between the TyG index and diabetes risk in individuals with normal FPG and TG levels. Our findings suggest that a TyG index exceeding 8.41 correlates with a progressively higher risk of diabetes development. These results collectively suggest the TyG index could serve as a clinically relevant predictor of diabetes incidence in this population.