AUTHOR=Yu Lin , Chen Haizhu , Zhang Jiwen , Han Wei 

TITLE=Triglyceride-glucose index and mortality in congestive heart failure with diabetes: a machine learning predictive model

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1675152

DOI=10.3389/fendo.2025.1675152

ISSN=1664-2392

ABSTRACT=BackgroundThe triglyceride-glucose (TyG) index serves as a marker for insulin resistance. Research exploring the link between the TyG index and adverse outcomes among patients suffering from congestive heart failure (CHF) and diabetes mellitus (DM) is limited. This investigation endeavors to uncover the connection between the TyG index and mortality risk in subjects suffering from CHF and DM.MethodsWe obtained clinical data for patients with CHF and DM from the MIMIC-IV (3.1) database. The optimal cutoff value for the TyG index was determined using X-tile software, and patients were classified into three groups. The primary outcome was 28-day hospital mortality, and the secondary outcome was 28-day ICU mortality. We used restricted cubic splines (RCS), COX regression analysis, and Kaplan-Meier survival curves to examine the association between the TyG index and adverse outcomes. Subgroup analyses were conducted based on age, gender, chronic pulmonary disease, atrial fibrillation, hypertension, and mechanical ventilation to assess the robustness of our findings. Feature selection was performed using LASSO regression, and predictive modeling was carried out using machine learning algorithms.ResultsThis study included 1046 patients with CHF and DM. Using a fully adjusted COX regression model, we identified a significant association between the TyG index and both 28-day hospital mortality (HR=1.31, 95% CI: 1.09–1.57, P=0.004) and 28-day ICU mortality (HR=1.29, 95% CI: 1.07–1.54, P=0.006). Using restricted cubic spline analysis, a linear link between the TyG index and mortality rates was found, indicating that a rise in TyG correlates with a heightened risk of unfavorable outcomes. The predictive performance was evaluated using seven machine learning algorithms, with the Random Survival Forest (RSF) algorithm achieving the best performance (AUC=0.817).ConclusionsIn patients with CHF and DM, TyG exhibited a linear correlation with both 28-day hospital mortality and 28-day ICU mortality. Elevated TyG values were significantly linked to a heightened risk of adverse events.