AUTHOR=Jemaneh Zekewos Demissie , Zemedkun Nahom , Nurlegn Serkalem , Woldeamanuel Amanuel Mamuye , Seife Henok , Birhanu Yohannes , Belachew Bethelhem Berhanu 

TITLE=Case report: Initial presentation of pancreatic schwannoma as cystic pancreatic mass treated with classic Whipple’s procedure

JOURNAL=Frontiers in Gastroenterology

VOLUME=Volume 3 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2024.1425831

DOI=10.3389/fgstr.2024.1425831

ISSN=2813-1169

ABSTRACT=Pancreatic schwannomas are exceedingly rare tumors arising from Schwann cells of the peripheral nerve sheath within the pancreas. Often asymptomatic or presenting with nonspecific symptoms, these tumors pose a diagnostic challenge due to their mimicry of other pancreatic neoplasms on imaging studies. Histologically, pancreatic schwannomas demonstrate spindle cell proliferation with a distinct Immunohistochemical profile, including positive staining for S-100 protein. Surgical resection remains the cornerstone of treatment, with excellent long-term prognosis following complete excision. Here, we present a case report of a pancreatic schwannoma in a woman presenting with a cystic pancreatic mass, underscoring the importance of considering this rare entity in the differential diagnosis of pancreatic lesions.