AUTHOR=Tiwari Hemant K., Patki Amit , Lieberman Jeffrey , Stroup T. Scott , Allison David B., Leibel Rudolph L., Chung Wendy K.

TITLE=Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)

JOURNAL=Frontiers in Genetics

VOLUME=volume 2 - 2011

YEAR=2011

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2011.00056

DOI=10.3389/fgene.2011.00056

ISSN=1664-8021

ABSTRACT=Antipsychotic drugs are widely used in treating schizophrenia, bipolar disorder, and other psychiatric disorders. Many of these drugs, despite their therapeutic advantages, substantially increase body weight.  We assessed the association of alleles of 31 genes implicated in body weight regulation with weight gain among patients being treated with specific antipsychotic medications in the CATIE trial, we found that rs2237988 in  ATP-binding cassette subfamily C member 8 (ABCC8) , and rs11643744 and rs9922047 in Fat Mass and Obesity Associated (FTO) were associated with such weight gain.