AUTHOR=Liu Jinping , Kim Jeongkyu , Oberdoerffer Philipp 

TITLE=Metabolic modulation of chromatin: implications for DNA repair and genomic integrity

JOURNAL=Frontiers in Genetics

VOLUME=Volume 4 - 2013

YEAR=2013

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2013.00182

DOI=10.3389/fgene.2013.00182

ISSN=1664-8021

ABSTRACT=The maintenance of genomic integrity in response to DNA damage is tightly linked to controlled changes in the damage-proximal chromatin environment. Many of the chromatin modifying enzymes involved in DNA repair depend on metabolic intermediates as co-factors, suggesting that changes in cellular metabolism can have direct consequences for repair efficiency and ultimately, genome stability. Here we discuss how metabolites may contribute to DNA double-strand break (DSB) repair, and how alterations in cellular metabolism associated with both aging and tumorigenesis may affect the integrity of our genomes.