AUTHOR=English Jane A., Harauma Akiko , Föcking Melanie , Wynne Kieran , Scaife Caitriona , Cagney Gerard , Moriguchi Toru , Cotter David R.

TITLE=Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus

JOURNAL=Frontiers in Genetics

VOLUME=Volume 4 - 2013

YEAR=2013

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2013.00208

DOI=10.3389/fgene.2013.00208

ISSN=1664-8021

ABSTRACT=Omega-3 fatty acid (n-3 FA) deficiency is an environmental risk factor for schizophrenia, yet characterisation of the consequences of deficiency at the protein level in the brain is limited.  We aimed to identify the protein pathways disrupted as a consequence of chronic n-3 deficiency in the hippocampus of mice.  Fatty acid analysis of the hippocampus following chronic dietary deficiency revealed a 3-fold decrease (p