AUTHOR=Robert Francis , Pelletier Jerry 

TITLE=Exploring the Impact of Single-Nucleotide Polymorphisms on Translation

JOURNAL=Frontiers in Genetics

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00507

DOI=10.3389/fgene.2018.00507

ISSN=1664-8021

ABSTRACT=Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNP) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mutations on gene expression is still in its infancy. Here, we provide a framework to help understand how mutations present in genes can affect translational output.