AUTHOR=Li Ling , Zhuang Yingliang , Zhao Xingsen , Li Xuekun 

TITLE=Long Non-coding RNA in Neuronal Development and Neurological Disorders

JOURNAL=Frontiers in Genetics

VOLUME=Volume 9 - 2018

YEAR=2019

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00744

DOI=10.3389/fgene.2018.00744

ISSN=1664-8021

ABSTRACT=Long non-coding RNAs (lncRNAs) are transcripts which are usually more than 200nt at length, and do not have the protein-coding capacity. LncRNAs can be categorized based on their generation from distinct DNA elements, or derived from specific RNA processing pathways. During the past several decades, dramatic progresses have been made in understanding the regulatory functions of lncRNAs in diverse biological processes including RNA processing and editing, cell fate determination, dosage compensation, genomic imprinting and development, etc. Dysregulation of lncRNAs involves in multiple human diseases, especially neurological disorders. In this review, we summarized the recent progress about the function of lncRNAs and associated molecular mechanisms with a focus on neuronal development and neurological disorders.