AUTHOR=Parmeciano Di Noto Gisela , Molina María Carolina , Quiroga Cecilia 

TITLE=Insights Into Non-coding RNAs as Novel Antimicrobial Drugs

JOURNAL=Frontiers in Genetics

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.00057

DOI=10.3389/fgene.2019.00057

ISSN=1664-8021

ABSTRACT=<p>Multidrug resistant bacteria are a serious worldwide problem, especially carbapenem-resistant <italic>Enterobacteriaceae</italic> (such as <italic>Klebsiella pneumoniae</italic> and <italic>Escherichia coli</italic>), <italic>Acinetobacter baumannii</italic> and <italic>Pseudomonas aeruginosa</italic>. Since the emergence of extensive and pan-drug resistant bacteria there are few antibiotics left to treat patients, thus novel RNA-based strategies are being considered. Here, we examine the current situation of different non-coding RNAs found in bacteria as well as their function and potential application as antimicrobial agents. Furthermore, we discuss the factors that may contribute in the efficient development of RNA-based drugs, the limitations for their implementation and the use of nanocarriers for delivery.</p>