AUTHOR=Kuehner Janise N. , Bruggeman Emily C. , Wen Zhexing , Yao Bing 

TITLE=Epigenetic Regulations in Neuropsychiatric Disorders

JOURNAL=Frontiers in Genetics

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.00268

DOI=10.3389/fgene.2019.00268

ISSN=1664-8021

ABSTRACT=Precise genetic and epigenetic spatiotemporal regulation of gene expression in the mammalian central nervous system is critical in how the brain develops, functions and forms its complex circuitry between differentiated neurons. These neuronal differentiation processes are tightly regulated by epigenetic processes including DNA methylation, histone modifications and non-coding RNAs. Dysregulation of any of these pathways is detrimental to normal neuronal development and functions, which can result in devastating neuropsychiatric disorders, such as depression, schizophrenia, and autism spectrum disorders. In this review, we focus on the current understanding of epigenetic regulations in brain development and functions, as well as their implications in neuropsychiatric disorders.