AUTHOR=Cai Jiali , Li Mengying , Wang Xiang , Li Lei , Li Qi , Hou Zhaoyuan , Jia Hao , Liu Shiyuan 

TITLE=USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination

JOURNAL=Frontiers in Genetics

VOLUME=Volume 10 - 2019

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2019.01324

DOI=10.3389/fgene.2019.01324

ISSN=1664-8021

ABSTRACT=Snail is a prominent EMT transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevents Snail degradation by regulating the ubiquitination-mediated hydrolysis process. Our studies demonstrate that DUB family member, USP37, can deubiquitinate Snail and prevent degradation of Snail. USP37 is colocalized with Snail in the nucleus. Biologically, Up-regulated expression of USP37 promotes lung cancer cell migration, while depletion of Snail abolishes the effect of USP37. These data demonstrate that USP37 is a Snail specific deubiquitinase and also indicate a potential therapeutic target for metastasis.