AUTHOR=Mai Meifang , Jiang Yinlian , Wu Xiaoman , Liu Gengrong , Zhu Yaoli , Zhu Weiping 

TITLE=Association of TGF-β1, IL-4, and IL-10 Polymorphisms With Chronic Kidney Disease Susceptibility: A Meta-Analysis

JOURNAL=Frontiers in Genetics

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.00079

DOI=10.3389/fgene.2020.00079

ISSN=1664-8021

ABSTRACT=Background: Anti-inflammatory cytokine polymorphisms in the transforming growth factor-β1 (TGF-β1), interleukin-4 (IL-4) and IL-10 genes have been implicated as risk factors for chronic kidney disease (CKD), but the results from published studies are inconsistent. Our meta-analysis reviews and summarizes the cumulative evidence for these associations.

Methods: A systematic literature search of 5 databases was performed up to October 2019. Two authors independently extracted data and evaluated the quality of included studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated from random-effects or fixed-effects models using Stata 12.0. 

Results: Nineteen case-control studies from 11 countries satisfied our inclusion criteria and were included in the meta-analysis. Overall, the pooled analysis showed that TGF-β1 rs1800469 was associated with decreased susceptibility to CKD (CC + TC vs TT, OR=0.33, 95% CI: 0.15-0.76, P=0.009; CC vs TT, OR=0.33, 95% CI: 0.15-0.73, P=0.006), whereas TGF-β1 rs1800471 was associated with increased CKD susceptibility (CC vs CG + GG, OR=1.68, 95% CI: 1.02-2.77, P=0.041; ). In stratified analyses based on ethnicity, TGF-β1 rs1800469 was associated with CKD susceptibility in Asians and Caucasians, and there was an association of TGF-β1 rs1800470 and IL-4 rs8179190 with CKD in Asians. Stratified analyses also associated TGF-β1 rs1800471 with CKD susceptibility in Caucasians. Neither overall meta-analyses nor stratified analyses identified an association of the IL-10 rs1800869 and rs1800871 polymorphisms with susceptibility to CKD.

Conclusions: Available data suggest that common polymorphisms in the TGF-β1 and IL-4 genes including rs1800469, rs1800470, rs1800471 and rs8179190 may be important genetic contributors to CKD susceptibility.