AUTHOR=Belokopytova Polina , Fishman Veniamin 

TITLE=Predicting Genome Architecture: Challenges and Solutions

JOURNAL=Frontiers in Genetics

VOLUME=Volume 11 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2020.617202

DOI=10.3389/fgene.2020.617202

ISSN=1664-8021

ABSTRACT=Genome architecture plays a pivotal role in gene regulation. Use of the high throughput methods
for chromatin profiling and 3D-interactions mapping provided rich experimental datasets
describing genome organization and dynamics. These data challenges development of new
models and algorithms connecting genome architecture with epigenetic marks and predicting
changes of chromatin interactions during normal development and in course of diseases. In this
review, we describe how chromatin architecture could be reconstructed from epigenetic data
using biophysical or statistical approaches. We discuss the applicability and limitations of these
methods for understanding mechanisms underlying chromatin architecture and scoring effects of
structural variations in human cells.