AUTHOR=Razzaq Abdul , Zafar Muhammad Mubashar , Ali Arfan , Hafeez Abdul , Sharif Faiza , Guan Xueing , Deng Xiaoying , Pengtao Li , Shi Yuzhen , Haroon Muhammad , Gong Wankui , Ren Maozhi , Yuan Youlu TITLE=The Pivotal Role of Major Chromosomes of Sub-Genomes A and D in Fiber Quality Traits of Cotton JOURNAL=Frontiers in Genetics VOLUME=Volume 12 - 2021 YEAR=2022 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.642595 DOI=10.3389/fgene.2021.642595 ISSN=1664-8021 ABSTRACT=Gossypium hirsutum L. is the most important tetraploid species cultivated over 33 million acres worldwide. The precise information about candidate genes involved in complex quantitative traits is a great hindrance to fiber quality improvement. As a result, the overall genetic gain is low in traditional phenotypic selection. Recent molecular interventions and advancements in genome sequencing have led to the development of high-throughput molecular markers, quantitative trait loci (QTL) fine mapping, and single nucleotide polymorphisms (SNPs) with genetic identification have resolved the existing bottlenecks in trait-specific breeding. This review demonstrates the significance of chromosomes 3, 7, 9, 11, and 12 of sub-genomes A and D carrying candidate genes for fiber quality. However, chromosome 7 carrying SNPs for stable and potent QTLs related to fiber quality provides great insights for fiber quality targeted research. This information can be validated by marker-assisted selection (MAS) and transgene in Arabidopsis and subsequently in cotton.