AUTHOR=Marí-Beffa Manuel , Mesa-Román Ana B. , Duran Ivan 

TITLE=Zebrafish Models for Human Skeletal Disorders

JOURNAL=Frontiers in Genetics

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.675331

DOI=10.3389/fgene.2021.675331

ISSN=1664-8021

ABSTRACT=During recent years, zebrafish has emerged as an interesting model species to evaluate chemical treatments against human skeletal dysplasia. Due to its versatility and low cost of experiments, zebrafish models are now available to analyze the genetic and developmental bases of about 100 human skeletal dysplasia. This offer is also complementary to mammalian models in the search for therapeutic drugs against diseases such as osteogenesis imperfecta, skeletal ciliopathies, dwarfisms, dysostoses or osteopetrosis related disorders among many other skeletal dysplasias. In this article, we review the state-of-art of this “aquarium to bedside” approach and the expected venues that arise from these studies.