AUTHOR=Liu Dong , Song Meixuan , Jing Fengchuan , Liu Bin , Yi Qijian 

TITLE=Diagnostic Value of Immune-Related Genes in Kawasaki Disease

JOURNAL=Frontiers in Genetics

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.763496

DOI=10.3389/fgene.2021.763496

ISSN=1664-8021

ABSTRACT=Kawasaki disease (KD) is a systemic vasculitis that predominantly damages medium and small-sized vessels, mainly causes coronary artery lesions(CALs). The diagnostic criterion of KD mainly depends on clinical features, so children are easy to suffer from missed diagnosis and CALs. Through analysis, a total of 14 immune-related DEGs were obtained, of which IL1B, ADM, PDGFC and TGFA were identified as diagnostic markers of KD. Compared with non-KD group, KD patients contained a higher proportion of naive B cells, activated memory CD4 T cells, gamma delta T cells and neutrophils, while the proportions of memory B cells, CD8 T cells, activated memory CD4 T cells and activated NK cells were relatively lower. In conclusion, Immune-related genes can be used as diagnostic markers of KD, the difference in immune cells between KD and non-KD might provide new insight in understanding the pathogenesis of KD.