AUTHOR=Wei Wan , Xuan Xianjun , Zhu Jiahui , Chen Tianwen , Fang Yudan , Ding Jiao , Ji Danfei , Zhou Guoyi , Tang Bo , He Xudong 

TITLE=EDNRA Gene rs1878406 Polymorphism is Associated With Susceptibility to Large Artery Atherosclerotic Stroke

JOURNAL=Frontiers in Genetics

VOLUME=Volume 12 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.783074

DOI=10.3389/fgene.2021.783074

ISSN=1664-8021

ABSTRACT=Objective: We performed this study to investigate whether the EDNRA gene rs1878406 C >T polymorphism is associated with risk of large artery atherosclerosis (LAA) stroke in Chinese Han population. 
Methods: Genotyping of rs1878406 was performed in 1112 LAA stroke patients and 1192 healthy controls. Multivariate logistic regression analyses were applied to assess the effect of the rs1878406 C >T polymorphism on susceptibility to LAA stroke. 
Results: A significant increase of LAA stroke risk was found in the recessive model (TT vs. CC/TC, OR=1.74, 95%CI=1.23-2.48, P=0.002) and co-dominant model (TC vs. CC, OR=1.06, 95% CI=0.89-1.27, TT vs. CC, OR=1.79, 95% CI=1.25-2.55, P=0.006) . However, the interaction between age and genotypes of rs1878406 was not statistically significant, and no significant interactive effect was observed between the rs1878406 C > T polymorphism and sex (P > 0.05).
Conclusion: The rs1878406 C >T polymorphism is associated with increased risk of LAA stroke in the Chinese Han population.