AUTHOR=Tong Zhoujie , Qi Jia , Ma Weixuan , Wang Di , Hu Boang , Li Yulin , Jia Xu , Peng Jie , Wang Zhihao , Zhong Ming 

TITLE=SUMO4 Gene SNP rs237025 and the Synergistic Effect With Weight Management: A Study of Risk Factors and Interventions for MetS

JOURNAL=Frontiers in Genetics

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.786393

DOI=10.3389/fgene.2021.786393

ISSN=1664-8021

ABSTRACT=Aim: Metabolic Syndrome (MetS) is widely prevalent across the world. Gene targeted therapy and risk management are promising approaches in MetS intervention. SUMO4 gene rs237025 polymorphism related to an increased risk in diabetes, therefore, is considered a target for MetS gene polymorphism research. 
Methods: A case-control study was performed to study the interaction of rs237025 with MetS and MetS components. A 5-year follow-up survey was carried out to elucidate the crosstalk between rs237025 and weight management on MetS. 
Results: A total of 1008 MetS patients and 1047 controls were recruited in this research. By cross-section study, we find rs237025 is an independent risk factor for increased Waist Circumference (WC), elevated Triglyceride (TG), elevated Fasting Plasma Glucose (FPG) as well as MetS. Cross-over analysis identifies the interaction of rs237025 and weight management as a risk factor for MetS, the synergistic effects of rs237025 and weight management on WC, TG, and High-density Lipoprotein-cholesterol (HDL-c) are negative.
Conclusion: SUMO4 gene rs237025 is related to increased risk of MetS, weight management is potentially beneficial to MetS, especially to patients with rs237025 polymorphism.