AUTHOR=Fang Gang , Huang Zhennan , Wang Zhongrui TITLE=Predicting Ischemic Stroke Outcome Using Deep Learning Approaches JOURNAL=Frontiers in Genetics VOLUME=Volume 12 - 2021 YEAR=2022 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.827522 DOI=10.3389/fgene.2021.827522 ISSN=1664-8021 ABSTRACT=Predicting functional outcomes after an Ischemic Stroke (IS) is highly valuable for patients and desirable for clinicians. This allows clinicians to set reasonable goals for patients and cooperate with patients and relatives effectively, furthermore to reach shared after-care decisions for recovery and make exercise plan to facilitate rehabilitation. The aim of this study was to apply various Deep learning (DL) approaches for 6-month stroke outcome predictions, using openly accessible International Stroke Trial (IST) dataset. Furthermore, another objective of this study is to compare performance of various DL approaches with Machine learning (ML) for clinical prediction modeling. After comparing various ML methods (Deep Forest, Random Forest, Support Vector Machine, etc.) with current DL frameworks (CNN, LSTM, Resnet), there are no evidence of superior performance of DL over ML. Improvements in methodology and reporting are needed for studies that compare modeling algorithms.