AUTHOR=Du Guanghui , Zhang Qi , Huang Xiaobo , Wang Yi 

TITLE=Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1018829

DOI=10.3389/fgene.2022.1018829

ISSN=1664-8021

ABSTRACT=Ferroptosis is an iron-dependent programmed cell death, which is different from apoptosis, necrosis and autophagy. The main mechanism of iron death is that, under the action of divalent iron or ester oxygenase, the unsaturated fatty acids which are highly expressed on the cell membrane are catalyzed to produce lipid peroxidation, thus inducing cell death. In addition, the expression of antioxidant system (glutathione (GSH) and glutathione peroxidase 4(GPX4)) was decreased. Iron death plays an important role in the development of diabetes mellitus and its complications. In this article, we reviewed the role of the molecular mechanism of iron death in the development of diabetes mellitus and its complications. We also summarized the emerging questions in this particular area of research, some of which remain unanswered. Overall, this is a comprehensive review focusing on ferroptosis mediated diabetes and providing novel insight in the treatment of diabetes from the ferroptosis perspective.